Understanding how genes control lymphatic development in newborns
Epigenetic regulation of lymphatic development
This study is looking at how certain genetic factors affect the development of lymphatic vessels in newborns, especially for those who have trouble breathing due to fluid buildup in their lungs, with the hope of finding new ways to help these babies breathe better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10856921 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic factors in the development of lymphatic vessels in newborns, particularly focusing on conditions that lead to the accumulation of chyle in the pleural space. By examining how these genetic mechanisms influence lymphatic function, the study aims to uncover the causes of severe respiratory issues in neonates, such as bilateral pleural effusion and respiratory distress. The approach includes both laboratory studies and clinical observations to better understand the relationship between lymphatic development and respiratory health in infants. The ultimate goal is to identify potential therapeutic targets for improving outcomes in affected newborns.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns diagnosed with congenital chylothorax or related lymphatic disorders.
Not a fit: Patients who are older than 4 weeks or do not have any lymphatic development issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve respiratory health and survival rates in newborns with lymphatic anomalies.
How similar studies have performed: While there have been historical observations of lymphatic anomalies, this research aims to explore novel epigenetic mechanisms that have not been extensively studied before.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Trivedi, Chinmay M — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Trivedi, Chinmay M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.