Understanding how genes control lung cell development
Gene regulatory networks in early lung epithelial cell fate decisions
['FUNDING_R01'] · STATE UNIVERSITY OF NEW YORK AT BUFFALO · NIH-11014379
This study is exploring how to guide stem cells to become healthy lung cells, which could lead to new treatments for lung diseases, especially by using cells tailored to individual patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NEW YORK AT BUFFALO (nih funded) |
| Locations | 1 site (AMHERST, UNITED STATES) |
| Trial ID | NIH-11014379 on ClinicalTrials.gov |
What this research studies
This research focuses on the gene regulatory networks that influence the fate of lung epithelial cells, particularly during early development. By investigating how stem cells can be guided to differentiate into specific lung cell types, the project aims to develop therapies for lung diseases. The approach involves using induced pluripotent stem cells (iPSCs) to create patient-specific treatments, which could enhance the body's natural repair mechanisms or provide new cells for transplantation. The research seeks to uncover the genetic pathways that dictate how these stem cells develop into functional lung cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with alpha-1 antitrypsin deficiency or other lung epithelial disorders who are 21 years or older.
Not a fit: Patients with lung diseases not related to epithelial cell dysfunction or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for patients with lung diseases, potentially improving lung function and quality of life.
How similar studies have performed: Previous research has shown promise in using stem cell technology for regenerative medicine, indicating potential success for this approach.
Where this research is happening
AMHERST, UNITED STATES
- STATE UNIVERSITY OF NEW YORK AT BUFFALO — AMHERST, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IKONOMOU, LAERTIS — STATE UNIVERSITY OF NEW YORK AT BUFFALO
- Study coordinator: IKONOMOU, LAERTIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.