Understanding how genes control lung cell development
Official title: Gene regulatory networks in early lung epithelial cell fate decisions
Funded at State University of New York at Buffalo · NIH-11014379 · Data updated 2026-11-12
This study is exploring how to guide stem cells to become healthy lung cells, which could lead to new treatments for lung diseases, especially by using cells tailored to individual patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $554,346 |
| NIH project number | 5R01HL158965-03 |
| Project ID | NIH-11014379 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with alpha-1 antitrypsin deficiency or other lung epithelial disorders who are 21 years or older.
✕Less likely to help
Patients with lung diseases not related to epithelial cell dysfunction or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on the gene regulatory networks that influence the fate of lung epithelial cells, particularly during early development. By investigating how stem cells can be guided to differentiate into specific lung cell types, the project aims to develop therapies for lung diseases. The approach involves using induced pluripotent stem cells (iPSCs) to create patient-specific treatments, which could enhance the body's natural repair mechanisms or provide new cells for transplantation. The research seeks to uncover the genetic pathways that dictate how these stem cells develop into functional lung cells.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for patients with lung diseases, potentially improving lung function and quality of life.
How similar studies have gone: Previous research has shown promise in using stem cell technology for regenerative medicine, indicating potential success for this approach.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Ikonomou, Laertis — State University of New York at Buffalo
- Study coordinator: Ikonomou, Laertis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.