Understanding how genes control kidney cell growth and development
Epigenetic mechanisms of gene regulation in nephron progenitor cell proliferation and differentiation
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10891608
This study is looking at how certain cells in the kidneys grow and change to help create healthy kidneys, which could help us understand kidney problems like renal hypoplasia and chronic kidney disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10891608 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that regulate gene expression in nephron progenitor cells, which are crucial for the formation of healthy kidneys. By studying how these cells balance self-renewal and differentiation, the research aims to uncover the chromatin changes that dictate the development of specific kidney cell types. The approach involves identifying key proteins and regulatory elements that influence gene expression during kidney development, which could lead to insights into conditions like renal hypoplasia and chronic kidney disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals under 21 years old who may be affected by kidney development issues or chronic kidney disease.
Not a fit: Patients with fully developed kidneys and no history of kidney-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating kidney diseases related to abnormal nephron development.
How similar studies have performed: While individual factors in kidney development have been studied, this research explores a novel approach to understanding the cooperative mechanisms of gene regulation in nephron progenitor cells.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAUCHMAN, MICHAEL I — WASHINGTON UNIVERSITY
- Study coordinator: RAUCHMAN, MICHAEL I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.