Understanding how genes control human brain development
Defining gene regulatory networks driving cortical evolution and brain development
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11063261
This project aims to discover how genes regulate the growth and development of the human brain, which could help us understand neuropsychiatric disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11063261 on ClinicalTrials.gov |
What this research studies
Our unique cognitive and social abilities come from the human brain's growth, and problems with this development can lead to neuropsychiatric disorders. We are exploring how specific genetic regions, called gene regulatory elements, control the formation of brain cells in the developing human brain. By mapping these elements and the factors that turn genes on or off, we hope to uncover the fundamental processes behind brain development. This work uses advanced sequencing techniques to look at how genes are accessed and expressed in human brain tissue.
Who could benefit from this research
Good fit: This basic science project does not directly involve patient participation, but future studies building on this knowledge may seek individuals with neuropsychiatric disorders or those interested in brain development.
Not a fit: Patients seeking immediate therapeutic interventions or direct clinical care will not receive benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could provide a foundational understanding of human brain development, potentially leading to new insights into the causes and treatments for neuropsychiatric disorders.
How similar studies have performed: Other researchers have begun to identify gene regulatory elements in the human brain, and this project builds upon prior work by the researchers who have already validated some of these elements.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DE LA TORRE-UBIETA, LUIS — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: DE LA TORRE-UBIETA, LUIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.