Understanding how genes control facial development
Transcriptional Regulatory Networks of Craniofacial Development
This study is looking at how genes help shape the face as it develops, using mice to learn more about orofacial clefts, which are common birth defects, so we can better understand what causes them.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10878718 on NIH RePORTER |
What this research studies
This research investigates the complex process of craniofacial development, particularly focusing on how genes are regulated during this process. By using mouse models, which share similarities with human development, the study aims to construct transcriptional regulatory networks that dictate facial formation. The research employs advanced techniques like ATAC sequencing to analyze gene expression changes across different tissue types and developmental stages. Ultimately, the goal is to enhance our understanding of the genetic factors involved in orofacial clefting, a common birth defect.
Who could benefit from this research
Good fit: Ideal candidates for this research are expectant parents with a family history of craniofacial anomalies or those who have been diagnosed with conditions related to orofacial clefting.
Not a fit: Patients with craniofacial conditions unrelated to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for craniofacial birth defects.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation in developmental processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Li, Hong — University of Colorado Denver
- Study coordinator: Li, Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.