Understanding how genes control early development and prevent birth defects
ERK-mediated regulation of non-coding RNAs during development and disease
This research explores how special genetic instructions in egg cells guide early development and how problems with these instructions might lead to birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11158744 on NIH RePORTER |
What this research studies
We are looking into how egg cells prepare for a new life by carefully managing their genetic messages, called RNAs, which are crucial for a healthy start. These RNAs are loaded into the egg before birth and must be protected and then used at the right time during early development. Our work aims to uncover the precise ways these genetic messages are controlled, as errors in this process can affect egg quality and lead to developmental problems. By understanding these fundamental steps, we hope to learn more about the causes of birth defects and infertility.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients, but future clinical applications may benefit individuals experiencing infertility or those at risk of having children with birth defects.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the causes of birth defects and infertility, potentially guiding future strategies for prevention or treatment.
How similar studies have performed: Previous work in both C. elegans and mammalian models has successfully highlighted the importance of maternal genetic messages in determining egg quality and offspring development.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Arur, Swathi — University of Tx Md Anderson Can Ctr
- Study coordinator: Arur, Swathi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.