Understanding how genes control cell development and function
Defining gene regulatory networks controlling cell fate
This study is looking at how genes work together to help cells grow and do their jobs, using special techniques to see how these gene networks change over time and in different situations, which can help us understand diseases better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10860971 on NIH RePORTER |
What this research studies
This research investigates the complex networks of genes that determine how cells develop and function. By utilizing advanced techniques like single cell RNA sequencing and ATAC sequencing, the study aims to identify the specific regulatory mechanisms that control gene expression in different cell types. This approach allows for a detailed analysis of how these networks change over time and in response to various conditions, which is crucial for understanding diseases where these processes go awry.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve disruptions in gene regulatory networks, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to gene regulation or those who do not have a genetic component to their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic basis of diseases and potential therapeutic targets for treatment.
How similar studies have performed: Previous research using similar single cell sequencing techniques has shown promise in uncovering gene regulatory networks, indicating that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Roy, Sushmita — University of Wisconsin-Madison
- Study coordinator: Roy, Sushmita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.