Understanding how genes control breathing circuits in the brain
Genetic Control of Respiratory Motor Circuit Development, Connectivity and Maintenance
This study is looking at how certain genes help build and keep the brain circuits that control breathing, which could lead to new treatments for people with breathing problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11047837 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms that govern the development and maintenance of neural circuits responsible for breathing. By focusing on specific genes, particularly Hox5 transcription factors, the study aims to uncover how these genes influence the formation and connectivity of neurons in the brainstem and spinal cord. The research employs advanced mouse models to explore the timing and function of these genes in respiratory motor neurons, which are crucial for normal breathing. Patients with respiratory disorders may benefit from insights gained through this research, as it could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with respiratory disorders such as central sleep apnea or those at risk of respiratory failure.
Not a fit: Patients with respiratory issues unrelated to neural circuit dysfunction may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for respiratory disorders, enhancing the quality of life for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on neural circuits, suggesting potential for breakthroughs in this area.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Philippidou, Polyxeni — Case Western Reserve University
- Study coordinator: Philippidou, Polyxeni
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.