Understanding how genes control brain cell development
Developmentally Regulated Enhancers and Chromatin Architecture in Human Neurogenesis
This study is looking at how certain genetic pieces help shape brain cells during early development, which could lead to better understanding and treatments for brain-related disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11093527 on NIH RePORTER |
What this research studies
This research investigates the role of specific genetic elements called enhancers in the development of brain cells. By examining the three-dimensional organization of chromatin, the study aims to uncover how these enhancers interact with genes to influence cell fate during early human development. The research utilizes advanced techniques to analyze chromatin architecture and gene expression in human embryonic stem cells and neural stem cells. Patients may benefit from insights gained into neurodevelopmental disorders and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurodevelopmental disorders or those interested in the genetic basis of brain development.
Not a fit: Patients with conditions unrelated to neurodevelopment or those not affected by genetic factors may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodevelopmental disorders by enhancing our understanding of brain cell formation.
How similar studies have performed: Other research has shown promising results in understanding gene regulation through similar approaches, indicating potential for success in this area.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Placantonakis, Dimitris G. — New York University School of Medicine
- Study coordinator: Placantonakis, Dimitris G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.