Understanding how genes control bone cell development and function
Epigenetic Regulation of Osteoclastogenic Gene Expression: Factors, Targets, and Mechanisms
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-10754262
This study is looking at how certain genes help bone cells called osteoclasts work, which could help us understand and improve treatments for bone loss and related diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-10754262 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific genes in the development and function of osteoclasts, which are cells responsible for bone resorption. By examining how these genes are regulated through chromatin modifications, the study aims to uncover mechanisms that lead to bone disorders. The approach involves analyzing the activity of proteins that modify histones, which are crucial for gene expression in osteoclasts. Patients may benefit from insights gained into how to better manage or treat conditions related to bone loss and skeletal diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bone disorders, such as osteoporosis or other conditions that affect bone density and health.
Not a fit: Patients with non-bone-related health issues or those whose bone health is not affected by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bone disorders by targeting the underlying genetic mechanisms involved in bone resorption.
How similar studies have performed: Previous research has shown promise in understanding gene regulation in bone health, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AN, WOOJIN — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: AN, WOOJIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bone disorder, Bone Diseases