Understanding how genes communicate and are controlled in the genome
Mechanisms of enhancer-promoter communication, genome organization and transcription control
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11066442
This study is looking at how different parts of our DNA work together to control how genes are turned on and off in our cells, using special imaging tools to see these interactions in real-time, which could help us understand more about health and diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11066442 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between enhancers and promoters in the genome, which are crucial for regulating gene expression in different cell types and conditions. By using advanced imaging techniques, the study aims to visualize these interactions in real-time within living cells. The researchers will explore how the structure of the genome influences these communications and how specific proteins contribute to this process. This work could provide insights into the fundamental mechanisms of gene regulation and their implications for health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that involve dysregulation of gene expression.
Not a fit: Patients with conditions unrelated to gene regulation or those who are not affected by genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, which may benefit patients with genetic disorders or diseases linked to gene regulation.
How similar studies have performed: Other research has shown success in understanding gene regulation mechanisms, but this specific approach using advanced imaging techniques is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PERTSINIDIS, ALEXANDROS — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: PERTSINIDIS, ALEXANDROS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.