Understanding how genes cause inflammation in the eye
Inflammatory Gene Transcription in the Retina
This study is looking into how changes in a specific gene called CAPN5 might cause a type of eye inflammation known as uveitis, especially for those with a genetic form of the condition, and it hopes to find new ways to help treat it by understanding how another protein, IRX3, is involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10760246 on NIH RePORTER |
What this research studies
This research investigates the molecular causes of uveitis, a challenging inflammatory eye disorder. It focuses on the CAPN5 gene, which is linked to a specific inherited form of uveitis called Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV). The study aims to explore how mutations in the CAPN5 gene lead to increased activity of a protein that regulates inflammation in the retina. By identifying the role of another protein, IRX3, in this process, the research seeks to uncover new therapeutic targets for treating uveitis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with uveitis, particularly those with a genetic predisposition to the condition.
Not a fit: Patients with uveitis caused by factors unrelated to genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from uveitis, potentially improving their quality of life.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in inflammatory diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Mahajan, Vinit B — Stanford University
- Study coordinator: Mahajan, Vinit B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.