Understanding how genes are turned on and off
Scalable platforms for understudied histone modifications and modifiers
This work helps us learn more about how our bodies control which genes are active, which is key to understanding many health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-11124183 on NIH RePORTER |
What this research studies
Our bodies' DNA is packaged with proteins called histones, forming something called chromatin, which acts like a control panel for our genes. Small changes to these histone proteins can turn genes on or off, influencing nearly all cellular processes and playing a role in many diseases. This project aims to develop new ways to study these important changes, especially those that are not well understood yet. By creating better tools, we can learn how these changes affect our health and what goes wrong in illness.
Who could benefit from this research
Good fit: This basic science work does not directly involve patients, but its findings could eventually benefit individuals with a wide range of conditions related to gene expression.
Not a fit: Patients seeking immediate treatment options or direct clinical participation would not find direct benefit from this foundational laboratory research.
Why it matters
Potential benefit: If successful, this foundational knowledge could lead to new ways to understand and potentially treat diseases linked to gene regulation.
How similar studies have performed: While some histone modifications are well-studied, this project focuses on developing new methods for the many modifications that remain largely unexplored.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Rao, Balaji M — North Carolina State University Raleigh
- Study coordinator: Rao, Balaji M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.