Understanding how genes are spliced and the role of circular RNAs in health and disease
Computational- and experimental- driven discovery of splicing regulation and circRNA function
This study is looking at how our genes can create different types of RNA and how this affects our health, especially in diseases, by exploring a new kind of RNA called circular RNA, which could help find new ways to diagnose and treat conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10990498 on NIH RePORTER |
What this research studies
This research investigates the complex process of alternative splicing, where genes are transcribed into different RNA forms, and how this process is regulated in various cell types and developmental stages. By exploring the function of circular RNAs, a recently discovered product of splicing, the research aims to uncover critical insights into gene expression and its implications for diseases. The approach combines computational analysis with experimental methods to identify RNA splice variants and their roles in health and disease, potentially leading to new biomarkers and therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases linked to splicing abnormalities.
Not a fit: Patients with conditions unrelated to genetic splicing or those who do not have identifiable genetic variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and treatments for diseases caused by genetic variants affecting splicing.
How similar studies have performed: Other research has shown promising results in understanding alternative splicing and its implications for disease, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Salzman, Julia — Stanford University
- Study coordinator: Salzman, Julia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.