Understanding how genes are regulated in yeast and humans
EPIGENOMIC REGULATION OF GENOMES
This study is exploring how genes are controlled in yeast and humans, using advanced techniques to understand the basic processes that affect our health and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10914946 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control gene regulation in both yeast and human systems. By initially studying the simpler yeast model, the researchers aim to dissect fundamental gene regulation processes that are common across all eukaryotic life. They utilize a cutting-edge technique called ChIP-exo to create detailed maps of protein-DNA interactions at a very high resolution. The findings from yeast will then be applied to human cells to enhance our understanding of gene regulation and its implications for health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases where gene regulation plays a critical role.
Not a fit: Patients with conditions unrelated to gene regulation or those not affected by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and treatment options for various diseases by enhancing our understanding of gene regulation.
How similar studies have performed: Previous research has shown success in using similar approaches to understand gene regulation, particularly in model organisms like yeast.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Pugh, B Franklin — Cornell University
- Study coordinator: Pugh, B Franklin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.