Understanding how genes are regulated in response to signals in cells
Official title: Dissecting the logic of mammalian gene regulation using synthetic biology and single-cell sequencing
Funded at University of Washington · NIH-10933421 · Data updated 2026-11-12
This study is looking at how genes in our cells react to signals during development to create different cell types, which could help us understand diseases like cancer and Alzheimer's better and lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 22, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $388,750 |
| NIH project number | 5DP5OD036167-02 |
| Project ID | NIH-10933421 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by Alzheimer's disease or related neuropsychiatric conditions.
✕Less likely to help
Patients with conditions unrelated to gene regulation or those not affected by neuropsychiatric diseases may not benefit from this research.
What this research studies
This research investigates how different genes in mammalian cells respond to external signals during development, leading to the formation of various cell types. By using synthetic biology and single-cell sequencing techniques, the study aims to decipher the complex interactions between genomic elements that control gene expression. This approach will help identify how disruptions in these processes can contribute to diseases like cancer and Alzheimer's. Patients may benefit from insights gained into gene regulation that could inform new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions like Alzheimer's disease by improving our understanding of gene regulation.
How similar studies have gone: Previous research has shown promise in using synthetic biology and CRISPR techniques to manipulate gene regulation, indicating potential success for this approach.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Pinglay, Sudarshan — University of Washington
- Study coordinator: Pinglay, Sudarshan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.