Understanding how genes are regulated in individual cells
Revealing cell-level gene regulation through integration of single-cell multi-omics measurements
This study is looking at how genes are controlled in individual cells using new technology, and it's designed to help scientists better understand how genes work in both healthy and sick cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10892940 on NIH RePORTER |
What this research studies
This research focuses on developing advanced computational methods to analyze gene regulation at the single-cell level using cutting-edge sequencing techniques. By integrating multi-omics measurements, the researchers aim to address challenges related to cell type imbalances and improve the accuracy of gene regulation inference. The study employs machine learning algorithms to explore various regulatory mechanisms, which could enhance our understanding of gene behavior in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve complex gene regulation, such as cancer or genetic disorders.
Not a fit: Patients with conditions unrelated to gene regulation or those who do not have a genetic component may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for diagnosing and treating diseases by providing deeper insights into gene regulation.
How similar studies have performed: Other research has shown promise in using single-cell sequencing and computational methods to understand gene regulation, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Wang, Yijie — Trustees of Indiana University
- Study coordinator: Wang, Yijie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.