Understanding how genes are regulated in cells using advanced technologies.
Official title: Methods for inferring and analyzing gene regulatory networks using single-cell multiomics and spatial genomics data
Funded at Columbia University Health Sciences · NIH-10916287 · Data updated 2026-11-12
This study is exploring how genes are controlled in our cells by looking closely at individual cells and their surroundings, which could help us create better treatments for different diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $406,218 |
| NIH project number | 5R35GM150887-02 |
| Project ID | NIH-10916287 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve complex gene regulation, such as cancer or genetic disorders.
✕Less likely to help
Patients with conditions that do not involve significant gene regulation issues may not benefit from this research.
What this research studies
This research investigates the complex mechanisms of gene regulation by utilizing cutting-edge single-cell multiomics and spatial genomics technologies. By analyzing both transcriptomic and epigenomic data from individual cells, the project aims to develop new computational methods that can better capture the dynamics of gene regulation over time and in specific tissue locations. This approach will enhance our understanding of how cells communicate and interact, which is crucial for designing targeted treatments for various diseases.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for diseases by providing insights into gene regulation and cell behavior.
How similar studies have gone: Other research has shown promise in using multiomics approaches to understand gene regulation, indicating that this methodology has potential for success.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Hou, Wenpin — Columbia University Health Sciences
- Study coordinator: Hou, Wenpin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.