Understanding how genes are regulated in cells using advanced computer models
Integrative computational models for functional epigenomics and transcriptional regulation
['FUNDING_OTHER'] · UNIVERSITY OF VIRGINIA · NIH-10841922
This study is looking at how genes work in different types of cells, which is important for keeping cells healthy, and it aims to help patients by finding out how problems with this process can lead to diseases, possibly leading to new treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10841922 on ClinicalTrials.gov |
What this research studies
This research investigates the complex process of how genes are turned on and off in different cell types, which is crucial for maintaining cell identity. By developing advanced computational models and statistical methods, the project aims to analyze large genomic datasets to better understand the role of transcription factors in gene regulation. Patients may benefit from insights gained about how dysregulation of these processes can lead to diseases, potentially informing new therapeutic strategies. The research will utilize big data from public genomic resources to enhance our understanding of transcriptional regulation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or diseases linked to transcriptional dysregulation.
Not a fit: Patients with conditions unrelated to gene regulation or transcriptional factors may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases caused by gene regulation errors.
How similar studies have performed: Previous research has shown promise in using computational models to understand gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZANG, CHONGZHI — UNIVERSITY OF VIRGINIA
- Study coordinator: ZANG, CHONGZHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.