Understanding how genes are regulated in cells
Mechanisms of transcriptional regulation and transcription factor specificity
['FUNDING_OTHER'] · FRED HUTCHINSON CANCER CENTER · NIH-11015005
This study is looking at how certain proteins help turn genes on and off in our cells, which is important for keeping our cells healthy, and it could help us understand diseases that happen when this process goes wrong.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11015005 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which specific proteins, known as transcription factors, regulate gene expression in cells. By utilizing advanced technologies, the research aims to uncover how these factors interact with other proteins and DNA to control the activation of genes essential for various cellular functions. The study focuses on understanding the specific roles of different coactivators and how they contribute to the assembly of the transcription machinery, which is crucial for proper cell growth and function. Insights gained from this research could lead to a better understanding of diseases linked to gene misregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene regulation disorders, such as certain cancers or developmental disorders.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by transcriptional regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases caused by gene expression errors.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation mechanisms, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAHN, STEVEN M — FRED HUTCHINSON CANCER CENTER
- Study coordinator: HAHN, STEVEN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.