Understanding how genes are regulated during transcription in humans
Probing co-transcriptional gene regulatory logics in human transcriptomes
This study is looking at how our genes work in human cells, especially how they are put together and controlled, to help us understand more about how gene expression changes in different health conditions, which could lead to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10928163 on NIH RePORTER |
What this research studies
This research investigates the complex processes that govern how genes are expressed in human cells, focusing on the role of splicing and transcription regulation. By using advanced genetic, molecular, and computational techniques, the team aims to uncover how different parts of genes interact to produce various transcripts. This could lead to a better understanding of gene regulation mechanisms that are crucial for normal development and disease. Patients may benefit from insights gained into how gene expression is altered in various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases that involve dysregulation of gene expression.
Not a fit: Patients with conditions unrelated to gene regulation or those who do not have genetic components to their diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to gene regulation abnormalities.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through similar molecular and computational approaches.
Where this research is happening
Boston, United States
- Boston University (Charles River Campus) — Boston, United States (Active)
Researchers
- Principal investigator: Fiszbein, Ana — Boston University (Charles River Campus)
- Study coordinator: Fiszbein, Ana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.