Understanding how genes are regulated during the formation of synapses in the brain
Official title: Regulation of Presynaptic Gene Transcripts During Synaptogenesis
Funded at Albert Einstein College of Medicine · NIH-10901073 · Data updated 2026-11-12
This study is looking at how a specific type of genetic material called mRNA helps brain cells connect with each other, using tiny worms to understand the process better, which could help us learn more about conditions like autism.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31NS137668-01 |
| Project ID | NIH-10901073 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old diagnosed with autism spectrum disorder (ASD).
✕Less likely to help
Patients with neurodevelopmental disorders not related to mRNA regulation or those over 21 years old may not benefit from this research.
What this research studies
This research investigates the regulation of messenger RNA (mRNA) during the process of synaptogenesis, which is crucial for the formation of connections between neurons. Using the model organism C. elegans, the study will explore how mRNA is transcribed, localized, and translated in living animals, particularly focusing on a key gene involved in presynaptic function. The researchers will employ advanced imaging techniques and mass spectrometry to observe the dynamics of mRNA and identify new regulatory factors that may influence neuronal development and function. This work aims to shed light on the molecular mechanisms underlying neurodevelopmental disorders, including autism spectrum disorder (ASD).
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors contributing to neurodevelopmental disorders, potentially informing future therapies.
How similar studies have gone: While the specific approach of studying mRNA regulation during synaptogenesis in C. elegans is novel, similar studies have shown success in understanding RNA dynamics in other contexts.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Rogow, Jackson a — Albert Einstein College of Medicine
- Study coordinator: Rogow, Jackson a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.