Understanding how genes are regulated during early development
Quantifying the dynamics of gene regulation and nuclear organization during embryogenesis
This study is looking at how genes are turned on and off during the early stages of development, using special imaging techniques to see how proteins work with DNA in real-time, which could help us understand more about how our bodies grow and what goes wrong in diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11159056 on NIH RePORTER |
What this research studies
This research investigates the complex processes that control gene expression during embryonic development. By utilizing advanced live imaging techniques, the study aims to observe how regulatory proteins interact with DNA in real-time, providing insights into the dynamic organization of the cell nucleus. The goal is to develop experimental methods that capture these processes in their natural tissue environments, rather than in isolated samples. This approach could lead to a better understanding of the fundamental mechanisms of development and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or developmental issues related to gene regulation.
Not a fit: Patients with conditions unrelated to gene regulation or embryonic development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation, potentially leading to new treatments for developmental disorders and cancers.
How similar studies have performed: Other research utilizing live imaging techniques has shown promise in understanding gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Mir, Mustafa Aized Hasan — Children's Hosp of Philadelphia
- Study coordinator: Mir, Mustafa Aized Hasan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.