Understanding how genes are regulated at the single-cell level
Revealing cell-level gene regulation through integration of single-cell multi-omics measurements
This study is looking at how tiny molecules called microRNAs work with messenger RNAs in individual cells to help us better understand gene regulation, which could lead to better ways to diagnose and treat diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10810174 on NIH RePORTER |
What this research studies
This research focuses on using advanced computational models to explore how microRNAs interact with messenger RNAs in individual cells. By employing a visible neural network model, the team aims to identify these interactions through single-cell multi-omics measurements. This approach will help develop new computational methods that enhance our understanding of gene regulation, which is crucial for improving disease diagnosis and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene regulation or those interested in the genetic basis of diseases.
Not a fit: Patients with conditions unrelated to gene regulation or those not affected by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise methods for diagnosing and treating diseases by understanding gene regulation better.
How similar studies have performed: Other research has shown promise in using computational models to understand gene interactions, indicating that this approach has potential for success.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Wang, Yijie — Trustees of Indiana University
- Study coordinator: Wang, Yijie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.