Understanding how genes are organized and move within the human genome
Official title: Gene positioning and dynamic chromatin organization of the human genome
Funded at Ohio State University · NIH-11080344 · Data updated 2026-11-12
This study is looking at how the structure of our DNA affects how genes work in different types of cells, using special imaging techniques to watch chromosomes move in real-time, which could help us better understand how our cells function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $382,636 |
| NIH project number | 5R35GM151095-03 |
| Project ID | NIH-11080344 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases that may be influenced by chromosomal organization and gene expression.
✕Less likely to help
Patients with conditions unrelated to chromosomal dynamics or gene expression may not benefit from this research.
What this research studies
This research investigates the three-dimensional organization of the human genome and how it affects gene expression in different cell types. Using advanced CRISPR-based imaging techniques, researchers will observe the dynamic movements of chromosomes in real-time under physiological conditions. The study aims to uncover how chromosomal territories are structured and how they change, which is crucial for understanding cellular functions and processes. By tracking multiple genomic loci simultaneously, the research seeks to reveal new insights into chromatin behavior and its implications for cell physiology.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic regulation and potential therapies for genetic disorders.
How similar studies have gone: Other research has shown promising results in understanding chromosomal dynamics, but this approach using advanced imaging techniques is relatively novel.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Tu, Li-Chun — Ohio State University
- Study coordinator: Tu, Li-Chun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.