Understanding how genes are organized and expressed in reproductive cells
Epigenetic mechanisms governing genome partitioning and gene expression in germ cells
This study is exploring how the genetic information in reproductive cells works together in a three-dimensional way, using tiny worms called C. elegans, to better understand how genes are controlled and expressed, which could help us learn more about reproduction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10591487 on NIH RePORTER |
What this research studies
This research investigates the complex organization of the genome in germ cells, which are essential for reproduction. By using the germ line of the model organism C. elegans, the study aims to uncover how genetic information is regulated and expressed through three-dimensional genome organization. The researchers will employ advanced techniques such as ChIP-seq and RNA-seq to analyze gene expression and epigenetic mechanisms in these cells. This work seeks to clarify the roles of various genetic elements and binding factors in maintaining proper gene function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders that may be related to germ cell function or genome organization.
Not a fit: Patients with conditions unrelated to germ cell biology or genome organization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic disorders linked to disruptions in genome organization, potentially informing new treatments.
How similar studies have performed: Other research has shown promising results in understanding genome organization and its implications for gene expression, making this approach both relevant and potentially impactful.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Reinke, Valerie J — Yale University
- Study coordinator: Reinke, Valerie J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.