Understanding how genes are expressed in living brains
Imaging cell-type-specific transcription in living mammalian brain
This study is looking at how different brain cells control the activity of genes in real-time, which could help us understand important processes like learning and development, and how this knowledge might relate to brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10925163 on NIH RePORTER |
What this research studies
This research investigates the dynamics of gene expression in the living mammalian brain, focusing on how different cell types regulate transcription in response to various contexts. By utilizing advanced imaging techniques, specifically intravital multiphoton microscopy, the study aims to visualize the behavior of mRNA molecules in real-time within specific brain cells. This approach will help uncover the complex regulatory mechanisms that govern gene expression during critical processes like development and learning. The ultimate goal is to enhance our understanding of transcriptional dynamics and its implications for neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders or those interested in the biological mechanisms of brain function.
Not a fit: Patients with conditions unrelated to gene expression or those outside the age range of 21+ years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating degenerative neurological disorders by revealing how gene expression is regulated in the brain.
How similar studies have performed: Previous research using similar imaging techniques has shown promise in understanding gene expression, indicating that this approach could yield valuable insights.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Lim, Hyungsik — Trustees of Indiana University
- Study coordinator: Lim, Hyungsik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.