Understanding how genes are expressed in different tissues during human development
Developmental GTEx Laboratory, Data Analysis and Coordination Center
This study is looking at how genes work in different parts of the body as people grow from ages 12 to 21, using samples from various tissues to help us understand how these changes might affect health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10868561 on NIH RePORTER |
What this research studies
This research focuses on mapping the transcriptional programs that determine how genes are expressed in various tissues throughout human development. By analyzing postmortem samples from individuals aged 12 to 21 years, the project aims to create a biobank of tissues, including the brain, gut, lung, and heart, to study how gene expression varies across different developmental stages. The research will utilize advanced techniques like ATAC sequencing to identify regulatory elements that may influence disease susceptibility. This comprehensive approach seeks to enhance our understanding of the genetic factors that contribute to health and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals aged 12 to 21 who are willing to contribute postmortem tissue samples for scientific analysis.
Not a fit: Patients outside the age range of 12 to 21 years or those who do not have postmortem tissue available will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved insights into the genetic basis of diseases, potentially informing better prevention and treatment strategies for patients.
How similar studies have performed: Previous research has shown success in similar approaches, particularly in understanding gene regulation and its implications for diseases, making this project a continuation of established scientific inquiry.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Ardlie, Kristin — Broad Institute, INC.
- Study coordinator: Ardlie, Kristin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.