Understanding how genes are controlled to prevent diseases
Deciphering Transcription Factor-Coregulator Interactions through Innovative Tools
This research aims to create new ways to study how genes are turned on and off, which could help us understand and prevent diseases like metabolic and neurodegenerative conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11177755 on NIH RePORTER |
What this research studies
Our bodies rely on special proteins called transcription factors and coregulators to manage how our genes work, influencing everything from development to how our cells respond to the environment. When these proteins don't work correctly, it can lead to various health problems, including metabolic issues and brain disorders. Current methods for studying these important protein interactions have limitations, such as difficulty getting consistent results or needing large sample sizes. We are developing advanced technologies, moving from older mass spectrometry techniques to new DNA barcode methods, to overcome these challenges. These new tools will allow us to study these gene-controlling proteins with greater precision and from smaller samples, giving us a clearer picture of their roles in health and disease.
Who could benefit from this research
Good fit: Patients with conditions linked to gene regulation, such as metabolic or neurodegenerative disorders, could indirectly benefit from the knowledge gained through this foundational research.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not receive direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide scientists with powerful new tools to better understand the root causes of many diseases, potentially leading to new ways to diagnose and treat them.
How similar studies have performed: This project aims to pioneer entirely new technologies to overcome limitations of existing methods, representing a novel approach in this field.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mohammed, Hisham — Oregon Health & Science University
- Study coordinator: Mohammed, Hisham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.