Understanding how genes are controlled in diseases like cancer using CRISPR technology
CRISPR-mediated Chemical Genetics Define Transcription Factor Gene Networks and Mechanisms of Control
This project uses a new CRISPR-based method to quickly understand how genes are turned on and off, which could help us learn more about diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11128773 on NIH RePORTER |
What this research studies
This project aims to understand how certain proteins, called transcription factors, quickly change how our genes work, which is important for cell health and disease. Currently, it takes a long time to see these changes, often missing the first, most important effects. Researchers are using a special CRISPR technique to rapidly turn off these transcription factors, allowing them to observe the immediate changes in gene activity. This faster approach helps uncover the direct ways these proteins influence cell behavior, especially in conditions like cancer.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation at this stage, but future clinical applications could benefit patients with various cancers.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project, as it focuses on fundamental biological mechanisms.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how diseases like cancer develop at a fundamental level, potentially identifying new targets for future treatments.
How similar studies have performed: CRISPR technology has shown great promise in genetic research, but this specific chemical-genetic approach for rapid transcription factor degradation is a novel method to overcome existing technical limitations.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Stengel, Kristy — Albert Einstein College of Medicine
- Study coordinator: Stengel, Kristy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.