Understanding how genes are controlled during embryo development
Design principles and dynamic gene control in embryonic development
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11011859
This study is exploring how genes are turned on and off during the early stages of development, using special techniques to see how different parts of DNA work together, which could help us understand both healthy and unhealthy growth in embryos.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11011859 on ClinicalTrials.gov |
What this research studies
This research investigates the complex mechanisms that regulate gene expression during embryonic development. By utilizing advanced techniques to analyze enhancer-promoter interactions at the single-cell level, the study aims to uncover how these interactions influence gene activity over time. The approach combines live imaging, genetic modifications, and mathematical modeling to provide a detailed understanding of gene regulation. This knowledge could lead to insights into normal and abnormal developmental processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders related to embryonic development or those interested in the underlying mechanisms of gene regulation.
Not a fit: Patients with fully developed conditions unrelated to genetic regulation or embryonic development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing developmental disorders and enhancing regenerative medicine.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through similar methodologies, indicating a strong potential for success in this area.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIM, BOMYI — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: LIM, BOMYI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease