Understanding how genes are active in different parts of cells and tissues
Computational methods for delineating subcellular and cellular spatial transcriptional heterogeneity along developmental trajectories
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11146411
This project creates computer tools to help us understand how gene activity varies within and between cells, which can change in healthy and diseased bodies.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11146411 on ClinicalTrials.gov |
What this research studies
Our bodies are made of many different cells, and how genes are turned on or off in these cells helps them do their jobs. Sometimes, in diseases, genes don't work quite right, leading to changes in how proteins are made or where they are located within a cell. This project develops advanced computer methods to carefully look at these subtle changes in gene activity, including how genes are 'edited' (alternative splicing) and where their instructions are found inside cells. By understanding these tiny differences, we hope to learn more about what causes diseases and how they progress. This knowledge could eventually lead to new ways to diagnose or treat various conditions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit future patients by improving our understanding of disease.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this computational methods development.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of disease origins and progression, potentially leading to new targets for diagnosis and treatment.
How similar studies have performed: While the specific computational methods are novel, the underlying biological concepts of gene expression and cellular heterogeneity are well-established areas of ongoing research.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FAN, JEAN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: FAN, JEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.