Understanding how genes and their variations affect disease in different populations
Haplotype-aware models of gene and isoform expression with application to genetic studies of disease in diverse populations
This study is looking at how different genes can affect your health and how likely you are to get certain diseases, so that in the future, you can get more personalized treatment based on your unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10974235 on NIH RePORTER |
What this research studies
This research focuses on developing advanced statistical methods to analyze how specific genetic variations influence gene expression and disease susceptibility. By utilizing large datasets, the project aims to create models that account for the unique genetic makeup of diverse populations. Patients may benefit from improved understanding of their genetic risks and more personalized approaches to treatment based on their genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from diverse genetic backgrounds who may be at risk for genetic diseases.
Not a fit: Patients with no genetic predisposition to the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate genetic assessments and targeted therapies for various diseases.
How similar studies have performed: Other research has shown promise in using genetic mapping techniques to improve disease understanding, indicating that this approach could yield significant insights.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Mohammadi, Pejman — Seattle Children's Hospital
- Study coordinator: Mohammadi, Pejman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.