Understanding how genes and the environment affect female reproductive health
Signaling mechanisms of gene-environment interactions in female reproductive
This study is looking at how certain genetic changes, especially in a gene called Map3k1, and environmental factors like pollution can affect women's reproductive health, with the hope of finding better ways to understand and treat issues like infertility and abdominal pain.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10594545 on NIH RePORTER |
What this research studies
This research investigates congenital anomalies of the female reproductive tract, which can lead to significant health issues such as infertility and severe abdominal pain. The study aims to explore the complex interactions between genetic factors and environmental influences, particularly focusing on a specific gene called Map3k1. By examining how mutations in this gene interact with environmental pollutants like dioxin, the research seeks to uncover the underlying mechanisms that contribute to these reproductive health issues. Patients may benefit from a better understanding of their conditions and potential new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing unexplained reproductive health issues, particularly those with congenital anomalies of the female reproductive tract.
Not a fit: Patients without congenital reproductive tract anomalies or those who do not experience related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for women with congenital reproductive tract anomalies.
How similar studies have performed: While the specific interactions being studied are novel, previous research has shown that understanding gene-environment interactions can lead to significant advancements in reproductive health.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Xia, Ying — University of Cincinnati
- Study coordinator: Xia, Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.