Understanding how genes and imaging data interact in brain tissue related to Alzheimer's disease
Causal Representation Learning for the Spatial Analysis of Transcriptomic and Imaging Data in Tissue Contexts
This study is looking at how genes behave in brain tissues affected by Alzheimer's disease by using advanced imaging and computer techniques, which could help us learn more about the disease and find new ways to understand and treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10471669 on NIH RePORTER |
What this research studies
This research investigates the integration of imaging and genomic data to better understand the spatial context of gene expression in brain tissues affected by Alzheimer's disease. By developing new computational methods, the project aims to analyze spatial transcriptomic data, which captures how genes are expressed in relation to their surrounding environment. The approach combines machine learning techniques to identify causal relationships and regulatory mechanisms that may contribute to the progression of Alzheimer's. This innovative framework seeks to enhance our understanding of the disease at a molecular level, potentially leading to new insights into its pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurological conditions or those without a diagnosis of Alzheimer's disease are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and therapeutic strategies for Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using integrated imaging and genomic approaches to understand complex diseases, suggesting that this methodology could yield valuable insights.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Uhler, Caroline — Broad Institute, INC.
- Study coordinator: Uhler, Caroline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.