Understanding how genes and environment interact to affect complex traits
Official title: Novel statistical genetics methods to unravel polygenic interactions in complex traits
Funded at University of Chicago · NIH-10915527 · Data updated 2026-11-12
This study is looking at how our genes and the environment work together to affect conditions like Major Depressive Disorder, with the goal of finding better ways to predict and treat these issues for everyone, not just those of European descent.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $401,296 |
| NIH project number | 5R35GM150822-02 |
| Project ID | NIH-10915527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with complex traits influenced by both genetic and environmental factors, particularly those with Major Depressive Disorder.
✕Less likely to help
Patients with purely monogenic disorders or those not affected by complex traits may not receive any benefit from this research.
What this research studies
This research focuses on the interactions between genetic factors and environmental influences that contribute to complex traits, such as Major Depressive Disorder. It aims to develop advanced statistical models that go beyond traditional methods, which often overlook these interactions. By identifying gene-gene and pathway-pathway interactions, the research seeks to provide a more accurate understanding of how these factors work together, potentially leading to better predictions and treatments for diseases. The study also addresses the bias in current genetic models that predominantly reflect European ancestry, aiming for a more equitable approach in genetic research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for complex traits, ultimately benefiting patients with conditions like Major Depressive Disorder.
How similar studies have gone: While there have been challenges in studying genetic interactions in the past, this approach aims to build on previous efforts and could represent a novel advancement in the field.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Dahl, Andrew — University of Chicago
- Study coordinator: Dahl, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.