Understanding how genes and environment cause birth defects of the head and face
Protein methylation pathways that control genetic susceptibility to environmental pollutants in the occurrence of craniofacial defects
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11114013
This research explores how certain proteins and environmental factors work together to cause birth defects in the head and face.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11114013 on ClinicalTrials.gov |
What this research studies
We know that birth defects of the head and face, like cleft palate, are often caused by a mix of genetic and environmental factors, but we don't fully understand how they interact. Our team recently found a new protein, PRMT1, that seems to protect against these defects, especially when exposed to environmental toxins. This project uses advanced laboratory techniques and mouse models to learn more about how PRMT1 works at a genetic level. By understanding these processes, we hope to uncover the specific ways environmental toxins contribute to these conditions.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the genetic and environmental causes of craniofacial birth defects, particularly those involving toxins like TCDD.
Not a fit: Patients seeking immediate new treatments or direct clinical participation will not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of why craniofacial defects occur, potentially guiding future strategies for prevention or treatment.
How similar studies have performed: Our team has recently identified a new regulator in this area, suggesting a novel approach to understanding these complex interactions.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XU, JIAN — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: XU, JIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.