Understanding how genes and cell types relate to opioid addiction
Single-cell resolution analysis of chromatin accessibility and gene expression changes in a model of drug addiction
['FUNDING_U01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10775784
This study is looking at how certain genes in brain cells might make some people more likely to become addicted to opioids like oxycodone, using a rat model to help us understand the changes that happen in the brain when someone struggles with addiction, which could help create better treatments in the future.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10775784 on ClinicalTrials.gov |
What this research studies
This research investigates the biological mechanisms behind opioid addiction by analyzing gene expression and chromatin accessibility at a single-cell level. Using a model of rats that have been trained to self-administer oxycodone, the study aims to identify specific cell types and their gene activity that may contribute to addiction vulnerability. By employing advanced sequencing techniques, researchers will gather detailed data from thousands of individual cells, providing insights into the neurobiological changes associated with compulsive drug use. This approach could lead to a better understanding of addiction and inform the development of more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have a history of opioid use or addiction.
Not a fit: Patients who do not have a history of opioid use or addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals struggling with opioid addiction.
How similar studies have performed: Previous research has shown promise in using single-cell analysis to understand complex conditions like addiction, indicating that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TELESE, FRANCESCA — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: TELESE, FRANCESCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Centers for Disease Control and Prevention, United States Centers for Disease Control, United States Centers for Disease Control and Prevention, Centers for Disease Control and Prevention (U.S.), Disorder