Understanding how genes and cell changes affect facial development
Genetic and epigenetic regulation of cranial neural crest differentiation
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-11113833
This research explores how genes and other cell changes guide the development of cells that form the face and head, aiming to understand birth defects like cleft lip.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11113833 on ClinicalTrials.gov |
What this research studies
Our bodies are built from cells that must develop in the right way at the right time and place. This project focuses on special cells called cranial neural crest cells, which are essential for forming the face and head. When these cells don't develop correctly, it can lead to common birth defects such as cleft lip and other craniofacial conditions. We are looking at how both genes and 'epigenetic' factors, which are changes around genes, control the precise timing and way these cells develop. By understanding this normal process, we hope to uncover why these birth defects occur.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future studies building on this work may seek individuals affected by craniofacial birth defects.
Not a fit: Patients not affected by birth defects related to cranial neural crest development would not directly benefit from this specific research.
Why it matters
Potential benefit: A deeper understanding of normal cell development could lead to new ways to prevent or treat birth defects affecting the face and head.
How similar studies have performed: While the specific mechanisms are being explored, previous research has established the critical role of neural crest cells in development and their link to birth defects.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARTINGER, KRISTIN — UNIVERSITY OF MINNESOTA
- Study coordinator: ARTINGER, KRISTIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.