Understanding how genes affect the development of hearing and balance cells in the inner ear
Epigenetics of inner ear neurosensory cell development
This study is looking at how changes in our DNA can affect the inner ear cells that help us hear and keep our balance, especially for people with conditions like CHARGE syndrome, to find new ways to understand and treat hearing loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10867455 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic changes in the development of inner ear cells responsible for hearing and balance. By examining how modifications to DNA and histone proteins influence gene expression, the study aims to uncover the mechanisms behind hearing and balance disorders. The research utilizes advanced techniques such as ATAC sequencing to analyze chromatin accessibility and gene regulation in patients with conditions like CHARGE syndrome. Insights gained may lead to better understanding and potential treatments for hearing loss.
Who could benefit from this research
Good fit: Ideal candidates include children and adults diagnosed with hearing or balance disorders, particularly those with genetic conditions like CHARGE syndrome.
Not a fit: Patients without hearing or balance disorders or those not affected by genetic factors related to inner ear development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for individuals suffering from hearing and balance disorders.
How similar studies have performed: Previous research has shown promising results in understanding the genetic and epigenetic factors influencing hearing loss, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Martin, Donna M. — University of Michigan at Ann Arbor
- Study coordinator: Martin, Donna M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.