Understanding how genes affect opioid use disorders
Transcriptional Regulation In Human Opioid Use Disorders
['FUNDING_P01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11158933
This study is looking at how our genes and brain cells might influence problems with opioid use, like addiction to heroin or fentanyl, to help find better ways to treat people struggling with these issues.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11158933 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and epigenetic factors that contribute to opioid use disorders (OUD) by focusing on specific brain regions involved in reward processing. Using advanced techniques like single nucleus RNA sequencing, the study analyzes individual cell types in the human brain and compares them to animal models to understand how opioids like heroin and fentanyl affect brain function. By examining these mechanisms at a cellular level, the research aims to uncover critical insights that could lead to better treatment strategies for OUD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with opioid use disorder who are seeking treatment or have a history of opioid use.
Not a fit: Patients who do not have a history of opioid use or are not diagnosed with an opioid use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals struggling with opioid use disorders.
How similar studies have performed: Previous research has shown promising results in understanding addiction through genetic and cellular analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HURD, YASMIN L. — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: HURD, YASMIN L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder