Understanding how genes affect opioid pain relief and side effects
Official title: Identifying Genetic Regulators of Opioid Signaling Bias
Funded at University of Florida · NIH-11160896 · Data updated 2026-11-12
This study is looking at how your genes might affect how well opioids work for pain relief, with the goal of finding ways to make pain management safer and more effective for everyone.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | May 23, 2025 |
| Project end | May 22, 2028 |
| Funding year | 2025 |
| Award (this year) | $74,284 |
| NIH project number | 1F32DA063102-01 |
| Project ID | NIH-11160896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who require opioid treatment for pain management and may be concerned about the associated risks.
✕Less likely to help
Patients who do not require opioid medications or those who are not experiencing pain may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence how opioids work in the body, particularly focusing on the µ opioid receptor (MOR) which is crucial for pain management. By examining a set of genetic candidates, the study aims to identify new regulators that affect the signaling pathways activated by opioids. This could lead to a better understanding of how to maximize pain relief while minimizing side effects like addiction and respiratory depression. Patients may benefit from insights that could lead to safer and more effective pain management strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved opioid treatments that provide effective pain relief with fewer side effects.
How similar studies have gone: Previous research has shown promise in identifying genetic factors that influence drug responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Rowe, Jacob Brandon — University of Florida
- Study coordinator: Rowe, Jacob Brandon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.