Understanding how genes affect fertility and germline development
Official title: RNA regulation in germline development and fertility
Funded at Icahn School of Medicine at Mount Sinai · NIH-10842759 · Data updated 2026-11-12
This study is looking into how certain cells that are crucial for reproduction develop and work, especially focusing on why women don't have some of these cells, with the hope of finding new ways to help couples facing infertility.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 2, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $470,347 |
| NIH project number | 1R35GM153244-01 |
| Project ID | NIH-10842759 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing infertility, particularly women facing challenges related to germline development and reproductive health.
✕Less likely to help
Patients who are not experiencing fertility issues or do not have concerns related to germline development may not benefit from this research.
What this research studies
This research investigates the genetic and molecular interactions that influence the development and function of germ cells, which are essential for reproduction. The team aims to uncover how germline stem cells are formed and why they are absent in women, as well as how the identity of these cells is maintained. By exploring these mechanisms, the research seeks to address issues related to infertility and extend reproductive options for women and their partners. The findings could lead to new strategies for preventing infertility and managing conditions related to reproductive health.
Why it matters
Potential benefit: If successful, this research could provide new insights and treatments to help individuals facing infertility and enhance reproductive choices.
How similar studies have gone: Other research has shown promise in understanding germline development and fertility, indicating that this area of study has the potential for significant advancements.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Marlow, Florence Louise — Icahn School of Medicine at Mount Sinai
- Study coordinator: Marlow, Florence Louise
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.