Understanding how genes affect diabetes in the pancreas
Multi-omic genetic regulatory signatures underlying tissue complexity of diabetes in the pancreas at single-cell spatial resolution
This work explores how genetic differences in the pancreas contribute to diabetes by looking closely at individual cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11124919 on NIH RePORTER |
What this research studies
Diabetes is a complex condition influenced by both our genes and our environment. This project focuses on understanding how genetic changes affect the insulin-producing cells in the pancreas, called beta cells, which are crucial for managing blood sugar. Researchers are using advanced techniques to map these genetic influences at a very detailed level, looking at specific cell types, age, sex, and genetic background. The goal is to uncover how genetic predispositions lead to diabetes by affecting how cells in the pancreas function.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals with adult-onset diabetes mellitus, particularly those interested in the genetic and cellular origins of their condition.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the root causes of diabetes, potentially paving the way for new ways to prevent or treat the disease.
How similar studies have performed: While specific to this detailed approach, genome-wide association studies have identified many genetic signals related to type 2 diabetes, providing a foundation for this deeper investigation.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Parker, Stephen Cj — University of Michigan at Ann Arbor
- Study coordinator: Parker, Stephen Cj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.