Understanding how genes affect brain development using mice
Brain development phenotyping of IMPC lethal mutant mice
This study is looking at special mice with genetic changes to understand how our brains develop and what might go wrong in conditions like autism or other brain disorders, so we can learn more about keeping brains healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10861897 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence brain development by studying specific mutant mice. By analyzing these mice, researchers aim to uncover the genes and processes that contribute to healthy brain formation and identify those that lead to neurodevelopmental disorders. The study employs a combination of broad phenotyping and targeted analysis of selected mutants to gain insights into brain structure and function. This work is particularly focused on lethal mutations that can provide valuable information about critical genes necessary for brain development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of neurodevelopmental disorders or those diagnosed with such conditions.
Not a fit: Patients with brain disorders not linked to genetic mutations or those without a family history of neurodevelopmental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic causes of brain disorders, potentially informing new treatments or preventive strategies.
How similar studies have performed: Previous research using similar genetic approaches in mouse models has successfully identified critical genes involved in brain development and related disorders.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Dwyer, Noelle D — University of Virginia
- Study coordinator: Dwyer, Noelle D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.