Understanding how genes affect brain cell identity in autism
Epigenetic Maintenance of Neural Cell Identity
This study is looking at how a gene called ZNF462 affects brain cell development, especially in people with autism and related conditions, to help us understand how changes in this gene might lead to challenges in brain function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11090459 on NIH RePORTER |
What this research studies
This research investigates the role of specific genes in maintaining the identity of neural cells, particularly in the context of neurodevelopmental disorders like autism. By focusing on a gene known as ZNF462, which is linked to Weiss-Kruszka syndrome, the research aims to uncover how mutations in this gene can disrupt normal brain development and function. The approach involves examining the interactions between ZNF462 and other proteins that modify chromatin, which is crucial for gene regulation. Patients may benefit from insights gained about the genetic factors contributing to autism and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include children under 11 years old who are diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
Not a fit: Patients with neurodevelopmental disorders not associated with the genetic factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new treatments for autism and other neurodevelopmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of neurodevelopmental disorders, indicating that this approach may yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Bell, Oliver — University of Southern California
- Study coordinator: Bell, Oliver
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.