Understanding how genes affect alcohol sensitivity and tolerance
Transcriptional Regulation of Alcohol Sensitivity and Tolerance
['FUNDING_R01'] · UNIVERSITY OF UTAH · NIH-11032816
This study is looking at how our genes and a special enzyme called Kdm3 affect how we react to alcohol, which could help us understand why some people are more sensitive to it than others, and it might lead to better treatments for those struggling with alcohol use.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11032816 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and molecular mechanisms that influence how individuals respond to alcohol, particularly focusing on the role of a specific enzyme called Kdm3. By studying the effects of alcohol on gene expression and chromatin modification, the research aims to identify how these changes contribute to alcohol sensitivity and tolerance. The approach involves using model organisms to observe the effects of Kdm3 on alcohol responses and to analyze the underlying neural pathways involved. Patients may benefit from insights gained into the biological factors that contribute to alcohol use disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who struggle with alcohol sensitivity or have a history of alcohol use disorder.
Not a fit: Patients who do not consume alcohol or have no history of alcohol-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating alcohol use disorders.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to alcohol sensitivity, suggesting that this approach may yield valuable insights.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROTHENFLUH, ADRIAN — UNIVERSITY OF UTAH
- Study coordinator: ROTHENFLUH, ADRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.