Understanding how genes affect alcohol sensitivity and tolerance
Official title: Transcriptional Regulation of Alcohol Sensitivity and Tolerance
Funded at University of Utah · NIH-11032816 · Data updated 2026-11-12
This study is looking at how our genes and a special enzyme called Kdm3 affect how we react to alcohol, which could help us understand why some people are more sensitive to it than others, and it might lead to better treatments for those struggling with alcohol use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | May 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $528,813 |
| NIH project number | 5R01AA030881-03 |
| Project ID | NIH-11032816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who struggle with alcohol sensitivity or have a history of alcohol use disorder.
✕Less likely to help
Patients who do not consume alcohol or have no history of alcohol-related issues may not benefit from this research.
What this research studies
This research investigates the genetic and molecular mechanisms that influence how individuals respond to alcohol, particularly focusing on the role of a specific enzyme called Kdm3. By studying the effects of alcohol on gene expression and chromatin modification, the research aims to identify how these changes contribute to alcohol sensitivity and tolerance. The approach involves using model organisms to observe the effects of Kdm3 on alcohol responses and to analyze the underlying neural pathways involved. Patients may benefit from insights gained into the biological factors that contribute to alcohol use disorders.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating alcohol use disorders.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors related to alcohol sensitivity, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Rothenfluh, Adrian — University of Utah
- Study coordinator: Rothenfluh, Adrian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.