Understanding how gene variations affect traits
Official title: Bayesian estimation of gene effects on traits from coding variants
Funded at Stanford University · NIH-11028719 · Data updated 2026-11-12
This study is looking at how certain rare gene changes can affect diseases, and it’s designed to help scientists better understand these effects so they can improve treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 9, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $666,831 |
| NIH project number | 1R01HG014005-01 |
| Project ID | NIH-11028719 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with rare genetic variants or those interested in the genetic basis of their health conditions.
✕Less likely to help
Patients without significant genetic variations or those not affected by the conditions being studied may not benefit from this research.
What this research studies
This research aims to identify key genes and molecular pathways that influence diseases by analyzing rare protein-coding variants. Using advanced Bayesian modeling techniques, the study will estimate how these genetic variations impact specific traits. By sharing information among similar genes, the researchers hope to improve the accuracy of their findings. The results will be made available through open access software and summary statistics, benefiting the broader scientific community.
Why it matters
Potential benefit: If successful, this research could lead to better understanding of genetic factors in diseases, potentially guiding new therapeutic interventions.
How similar studies have gone: Previous research using Bayesian approaches in genetics has shown promise, indicating that this methodology could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Pritchard, Jonathan K — Stanford University
- Study coordinator: Pritchard, Jonathan K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.