Understanding how gene splicing affects psychiatric disorders
Resolving complex alternative splicing of psychiatric disease genes using single-cell approaches
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11086786
This study is looking at how certain genes linked to mental health conditions like schizophrenia, bipolar disorder, and autism work in the brain, hoping to find new ways to understand and treat these conditions better for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11086786 on ClinicalTrials.gov |
What this research studies
This research investigates the complex ways in which genes related to psychiatric disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder, are spliced in the brain. Using advanced single-cell sequencing techniques, the study aims to catalog the different gene variants that may influence brain function and development. By focusing on how these variations affect neuronal maturation and synaptic function, the research seeks to uncover critical insights into the biological underpinnings of these disorders. Patients may benefit from a deeper understanding of their conditions and potential new treatment avenues based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with schizophrenia, bipolar disorder, or autism spectrum disorder.
Not a fit: Patients with psychiatric disorders not related to the specific genes being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals with psychiatric disorders.
How similar studies have performed: Other research has shown promise in understanding gene splicing in relation to psychiatric disorders, but this approach using single-cell sequencing is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FANG, GANG — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: FANG, GANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder