Understanding how gene silencing can be passed down through generations
Transgenerational gene silencing
This study is looking at how some changes in how genes work can be passed down through generations without changing the actual DNA, using tiny worms called C. elegans, to help us understand how things like stress can affect our genes and those of our children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project ID | NIH-10866587 on NIH RePORTER |
What this research studies
This research investigates how certain changes in gene expression can be inherited across generations without altering the DNA sequence itself. By studying the nematode C. elegans, the research aims to uncover the mechanisms behind these heritable epigenetic changes, particularly focusing on RNA-mediated regulation. The approach involves analyzing the interactions and regulatory architectures that sustain gene silencing over many generations. This could provide valuable insights into how environmental factors, such as stress, can influence genetic expression in descendants.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of conditions potentially influenced by epigenetic factors, such as those related to stress or trauma.
Not a fit: Patients who do not have a family history of epigenetically influenced conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new understanding of how epigenetic changes affect health and disease across generations.
How similar studies have performed: Other research has shown promising results in understanding epigenetic changes, but this specific approach focusing on regulatory architectures in C. elegans is relatively novel.
Where this research is happening
College Park, United States
- Univ of Maryland, College Park — College Park, United States (Active)
Researchers
- Principal investigator: Jose, Antony Merlin — Univ of Maryland, College Park
- Study coordinator: Jose, Antony Merlin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.